The cholinergic hypothesis of AD has been a staple of the field for many years. This hypothesis was the result of the classic studies showing a loss of cholinergic neurons in the basal forebrain and a ...

Like musical sounds, different states of mind are defined by distinct, characteristic waveforms, recognizable frequencies and rhythms in the electrical field of the brain. When the brain is alert ...

When a large combat unit, widely dispersed in dense jungle, goes to battle, no single soldier knows precisely how his actions are affecting the unit's success or failure. But in modern armies ...

Johns Hopkins University researchers, working with scientists at the National Institute on Aging, have identified the precise nerve cells that allow the brain to make this type of split-second change ...

After fasting for 24 hours the typical laboratory mouse spends much time eating. Surprisingly, this is not what Jay M. Patel saw when he was studying basal forebrain circuits in mice.

Neurons that die early in Alzheimer’s help drive brain waste removal. Treating this process sooner could change outcomes.

Degeneration and loss of cholinergic neurons in the basal forebrain has been implicated in Alzheimer's disease, age-related cognitive decline, and other cognitive disorders and dementias.

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proceedings of the National Academy of Sciences , 2015; 201413625 DOI: 10.1073/pnas.1413625112 ...