The research team plans to further refine their imaging technique and use it to study ATP dynamics in various models of kidney injury, including those related to diabetes, aging, and drug-induced ...

More information: Tze Hui Koh et al, Dimensionality reduction of calcium-imaged neuronal population activity, Nature Computational Science (2022). DOI: 10.1038/s43588-022-00390-2 ...

Researchers have developed a calcium sensor for use in magnetic resonance imaging (MRI) that they hope can one day track electrical activity in neurons deep in living brains. The tool potentially ...

Previous studies have revealed calcium ions to be one promising weapon in the fight to reverse resistance, showing promise in decreasing the levels of both P-gp and ATP.

The GCaMP calcium indicator consists of a fluorescent protein attached to a calcium-binding protein called calmodulin, and a calmodulin-binding protein called M13 peptide.

However, ATP dynamics—the changes over time in ATP production and utilization—within the kidney have been poorly understood because of the lack of suitable imaging technologies.

American Chemical Society. "Calcium bursts kill drug-resistant tumor cells." ScienceDaily. ScienceDaily, 16 October 2020. <www.sciencedaily.com / releases / 2020 / 10 / 201016132017.htm>.

However, ATP dynamics-; the changes over time in ATP production and utilization-; within the kidney have been poorly understood because of the lack of suitable imaging technologies.

This article presents a carefully described technique with some tips on successful imaging of calcium with Fura-2 AM in the ventral spinal motor neurons of the spinal cord. 1.