The complement membrane attack complex is a pore that inserts into the cell membrane. The complex is formed by up to 18 C9 subunits (purple), the C5, C6, and C7 subunits (various shades of green ...

The complement membrane attack complex is a pore that inserts into the cell membrane. The complex is formed by up to 18 C9 subunits (purple), the C5, C6, and C7 subunits (various shades of green ...

image: The complement membrane attack complex is a pore that inserts into the cell membrane. The complex is formed by up to 18 C9 subunits (purple), the C5, C6, and C7 subunits (various shades of ...

MAC forms a circular pore, closed at one end by the C8 proteins; the MAC pore permits the flow of ions through the outer membrane of cells. This pore is the final step in the 'complement cascade ...

The complement membrane attack complex is a pore that inserts into the cell membrane. The complex is formed by up to 18 C9 subunits (purple), the C5, C6, and C7 subunits (various shades of green ...

References [1] Structural basis for membrane attack complex inhibition by CD59. Nature Communications (2023). [2] Structure of the poly-C9 component of the complement membrane attack complex.

The monoclonal antibody targets the complement protein C5 and prevents it from cleaving into C5a and C5b, thereby inhibiting the membrane attack complex. 2,3 ...