In recent years, the Stevens laboratory has helped pioneer the structure determination of G protein-coupled receptors. Although the first crystallographic structures of opioid receptors were ...

Yoshioka, T., et al. (2024) Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert acute ...

The body's endogenous opioid system has three classes of opioid receptors: mu, delta, and kappa. Previous research showed that mice lacking the mu opioid receptor do not drink alcohol. A new study ...

Quick-acting targeted therapies with minimal side effects are an urgent need for the treatment of anxiety-related disorders. While delta opioid receptor (DOP) agonists have shown 'anxiolytic' or ...

Saitoh, A., et al. (2018). The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice.

Delta opioid receptor agonists exert antidepressant effects via the mTOR–PI3K signaling pathway (IMAGE) ...

Delta opioid receptors (DOPs) are known to play a key role in the development of depression and similar diseases. Previous studies have revealed that DOP agonists (substances that bind DOPs ...

The opioids your body produces and opioid drugs bind to the same receptors. The problem comes when you take an opioid drug like morphine or fentanyl, especially at high doses for a long time.

They increase dopamine signaling in the brain, producing pleasurable sensations that can encourage repeated use and, over time, lead to addiction. Both endogenous and illicit opioid molecules act ...

Non-opioid drugs like suzetrigine or the delta receptor compound could reduce this problem. They don’t mess with the brain’s reward system, so there’s less chance of addiction.