First-generation antipsychotics, dating back to the 1950s, targeted the postsynaptic dopamine 2 (D2) receptor. Chlorpromazine, the first of that class, was approved by the FDA in 1954. That was ...

Alterations in dopaminergic innervation and receptors in focal cortical dysplasia. Brain, 2025; DOI: 10.1093/brain/awaf080 ...

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new ...

"D1- and D2-like Receptors Differentially Mediate the Effects of Dopaminergic Transmission on Cost–Benefit Evaluation and Motivation in Monkeys." PLos Biology (First published: July 01, 2021 ...

"D1- and D2-like Receptors Differentially Mediate the Effects of Dopaminergic Transmission on Cost–Benefit Evaluation and Motivation in Monkeys." PLos Biology (First published: July 01, 2021 ...

Instead, it modulates the muscarinic receptors, which are involved in cognitive function and processing, as well as in modulating dopaminergic and glutamatergic systems indirectly.

The current study shows that the dopaminergic supply in the affected brain areas is altered. In addition, an increased expression of certain dopamine receptors was observed – both in human ...

"We showed that fear extinction requires VTA dopaminergic activity in the pBLA Ppp1r1b neurons by using optogenetic inhibition of VTA terminals and cell-type-specific knockdown of D1 receptors in ...