Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new ...

The current study shows that the dopaminergic supply in the affected brain areas is altered. In addition, an increased expression of certain dopamine receptors was observed – both in human ...

"D1- and D2-like Receptors Differentially Mediate the Effects of Dopaminergic Transmission on Cost–Benefit Evaluation and Motivation in Monkeys." PLos Biology (First published: July 01, 2021 ...

First-generation antipsychotics, dating back to the 1950s, targeted the postsynaptic dopamine 2 (D2) receptor. Chlorpromazine, the first of that class, was approved by the FDA in 1954. That was ...

"We showed that fear extinction requires VTA dopaminergic activity in the pBLA Ppp1r1b neurons by using optogenetic inhibition of VTA terminals and cell-type-specific knockdown of D1 receptors in ...

Alterations in dopaminergic innervation and receptors in focal cortical dysplasia. Brain, 2025; DOI: 10.1093/brain/awaf080 ...

In comparison with other antipsychotic agents, which act mainly as dopamine D 2 -receptor antagonists, aripiprazole is a partial agonist at D 2 receptors. [23, 24] Aripiprazole binds with high ...

"D1- and D2-like Receptors Differentially Mediate the Effects of Dopaminergic Transmission on Cost–Benefit Evaluation and Motivation in Monkeys." PLos Biology (First published: July 01, 2021 ...