The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the intricate arrangement of the glomerular endothelial cells, podocyte layers, and GBM in a single step.

Gunter Wolf; Sheldon Chen; Fuad N. Ziyadeh Disclosures Diabetes. 2005;54 (6):1626-1634.

In the paper titled, “ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease,” the authors reported ...

The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the intricate arrangement of the glomerular endothelial cells, podocyte layers, and GBM in a single step.

The absence of Adhesion G-protein-coupled receptor F5 (ADGRF5) led to significant changes in gene expression in glomerular endothelial cells, disrupting the structure and function of the ...

Initially, the researchers observed the specific expression of ADGRF5 within endothelial cells that line the glomerular capillary wall. In mice with genetic knockout of ADGRF5, the GFB was ...