In hospitals alone, 1,000 people per week die due to pressure ulcers. In diabetes patients, 84% of amputations are attributed to open wounds.

A serum (clear)-filled blister would be defined by both NPUAP and MDS as a stage II pressure ulcer, not a suspected deep tissue injury. From the September 01, 2009 Issue of McKnight's Long-Term ...

Stage 4: The ulcer exposes deeper subcutaneous tissue and possibly bones, tendons, muscles, or vital organs. Unstageable: The ulcer has full-thickness skin loss covered by slough or eschar.

Once the clot forms, your body will start building granulation tissue to cover the wound. This tissue often appears a creamy white color and consists of collagen, white blood cells, and blood vessels.