A groundbreaking study conducted by a research team from Kumamoto University has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings ...

TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic Acids Research, 2024; 52 (15): 9230 DOI: 10.1093/nar/gkae520 ...

A study conducted by a research team from Kumamoto University has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the ...

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis. Current Biology, March 2016 DOI: 10.1016/j.cub.2016.01.045 ...

During initiation, the small ribosomal subunit binds to the 5' end of the mRNA and scans along the mRNA until it reaches the start codon (AUG), which codes for the amino acid methionine. The large ...

Mammalian internal initiation uses subunit rolling Interestingly, the two subpopulations of the mammalian 80S–HCV-IRES–Met-tRNA iMet –eIF5B–GMPPNP complex (Fig. 2) are distinguished by the ...

We determined whether IF2 and tRNA binding is simultaneous, sequential or random by delivering a mixture of Cy3-labelled initiator tRNA (fMet- (Cy3)tRNA fMet), Cy5-labelled IF2 (Cy5–IF2) and Cy3 ...