Inhibiting MMP-12 with FP-020 attenuated macrophage infiltration, macrophage clustering, decreased fibrotic replacement, and reduced the number of activated fibroblasts.Mice with a conditional ...

They observed that HIV-infected macrophages secreted the zymogen matrix metalloproteinase 2 (MMP-2), which is activated by exposure to MT1-MMP on neurons. SDF-1—a chemokine overexpressed by astrocytes ...