Tiny immune cells called microglia protect the central nervous system (CNS) in a multitude of ways: They provide innate immunity, shape neurodevelopment, maintain homeostasis and modulate neurological ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

Scientists broadly agree that both apolipoprotein E and microglia are necessary ingredients for amyloidosis. In mice devoid of ApoE, or of their microglia, scant plaques form. Now, a sweeping study ...

Inflammation is triggered by the immune system and is part of the body’s natural response to injuries or disease. However, abnormal inflammation has recently been established as a hallmark for ...

Recursion, Roche, and its Genentech subsidiary have unveiled the latest product of their nearly four-year artificial intelligence (AI) drug discovery collaboration, a whole-genome map of specialized ...

In this interview, Dr. Tilman explains the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s and other neurodegenerative diseases. Microglia are the primary immune ...

How can scientists coax microglia to chew up more Aβ? In the November Alzheimer’s & Dementia, a group led by Rudolph Tanzi at Massachusetts General Hospital, Charlestown, revived an old idea. They ...

Neurological disease pathophysiology and injury is incredibly complex and temporally dynamic. This offers an overwhelming challenge in developing and appropriately using physiologically relevant ...