A base pair is a fundamental unit of double-stranded nucleic acids, such as DNA and RNA. It consists of two complementary nucleobases bound to each other by hydrogen bonds. The base pairing rules ...

DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

Relevant preliminary work: Stable Cu (I)-Mediated Base Pairing in DNA Jash B, Müller J, Angew. Chem. Int. Ed. 57, 9524-9527 (2018) A metal-mediated base pair that discriminates between the canonical ...

I'll first describe our new model of nucleic acid kinetics, based on Arrhenius principles. Unlike previous models, parameters of our model help account for ways in which the rate of nucleic acid base ...

The researchers developed so-called threofuranosyl nucleic acid (TNA) with a new, additional base pair. These are the first steps on the way to fully artificial nucleic acids with enhanced ...

Keystone Symposia: Nucleic Acid Therapeutics: From Base Pairs to Bedsides 10 - 15 January 2012, Santa Fe, New Mexico, United States Introduction The meeting will focus on pre- and post- ...

The meeting will focus on pre- and post- transcriptional gene silencing using oligodeoxynucleotides, small interfering RNA, microRNA and other nucleic acid-based molecules to develop effective drugs.