If you are studying nucleic acid structures in your lab, you may apply several methods to identify and characterize G4 structures and confirm their formation in your samples.

The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography. But more ...

Nucleic acid-based techniques, such as polymerase chain reaction (PCR) and DNA sequencing, are widely used in molecular diagnostics. These methods allow for the detection and identification of ...

WE have formulated a structure for the nucleic acids which is compatible with the main features of the X-ray diagram and with the general principles of molecular structure, and which accounts ...

The nucleic acid adenosine triphosphate (ATP), made up of an adenine nitrogenous base, a 5-carbon ribose sugar, and three phosphate groups, is involved in generating energy for cellular processes.

Spherical nucleic acids (SNAs) are structures that are made by taking nanoparticles and synthesizing short snippets of DNA or RNA that are terminated with groups that can chemically bond to the ...

These studies advance understanding of G-quadruplex dynamics, enabling accurate structure prediction from sequences. This can accelerate drug discovery targeting GQs, guide nucleic acid material ...