Pediatric Clinical Care Guidelines for Optic Pathway Gliomas Continuing our review of the newly published pediatric NF clinical care resource, the next issue to cover is the optic pathway glioma, ...

Journal reference: Jecrois , E.S., et al. (2021) Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.

A common goal of imaging in NF is to identify tumors in the nervous system, especially, in children, the presence of an optic glioma, which is a tumor of the optic pathway that occurs in 15% of ...

Abstract e22016 Background: Optic pathway gliomas (OPG) constitute 1-5% of childhood brain tumors. The presence of neurofibromatosis type 1 (NF-1) is generally associated with more indolent disease.

Researchers at Washington University School of Medicine in St. Louis have discovered that an FDA-approved epilepsy drug can prevent or slow the growth of NF1-linked optic gliomas in mice, laying ...

DETROIT, Sept. 14, 2021 /PRNewswire/ -- The Gilbert Family Foundation, a private nonprofit established by Jennifer and Dan Gilbert to accelerate a cure for neurofibromatosis type 1 (NF1), today ...

Children with NF type 1 (NF1) can develop a kind of brain tumor known as an optic pathway glioma. These tumors grow within the optic nerves, which carries messages between the eyes and the brain.

Session ID: 2025-06-02:e7f609d456fbd7ac63f937a5 Player Element ID: V938001c7_cd36_4bd2_8943_491394fccca7_6359211940112 ...

Two or more Lisch nodules. These are tiny bumps of the colored part of the eye (the iris). Certain bony deformities. A family history of NF1. Tumor of the optic nerve (called an optic glioma).

Purpose Optic pathway gliomas (OPGs) are the most common CNS tumor in neurofibromatosis 1 (NF1) patients. We evaluated the long-term risk of second tumors in NF1-related OPGs after radiotherapy.

NF1 mutation-driven neuronal hyperexcitability sets a threshold for tumorigenesis and therapeutic targeting of murine optic glioma. Neuro-Oncology, 2024; DOI: 10.1093/neuonc/noae054 ...