Scott’s structural observations of the hammerhead ribozyme, however, could not explain a growing number of biochemical experimental results. The hammerhead ribozyme has been the subject of intensive ...

The 24-3 ribozyme is thus the first ever to combine the two basic capabilities—RNA synthesis and RNA replication—necessary for a pre-protein, pre-DNA world of RNA life.

Atomic-resolution Structure Of A Ribozyme Yields Insights Into RNA Catalysis And The Origins Of Life Date: July 22, 2006 Source: University of California - Santa Cruz Summary: Scientists have ...

Article #19-14282: "An RNA polymerase ribozyme that synthesizes its own ancestor," by Katrina F. Tjhung, Maxim N. Shokhirev, David P. Horning, and Gerald F. Joyce.

More precisely: the ribozyme transfers a single methyl group to an exactly defined nitrogen atom of the target RNA. This makes it the first known methyl transferase ribozyme in the world. Accordingly, ...

FLIP THE SWITCH Breaker's team found the new ribozyme at one end of the messenger RNA that codes for an amidotransferase enzyme. When the mRNA is translated into protein, the enzyme produced makes ...

A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells. Nature Chemistry, 2023; DOI: 10.1038/s41557-023-01320-z ...

A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells. Nat Chem. 2023. doi: 10.1038/s41557-023-01320-z This article has been republished from the following materials. Note ...

The ribozyme came from E. coli, and the researchers engineered it to target two cytomegalovirus (CMV) genes.

The tetrahymena ribozyme Cech’s team discovered was an intron itself and evidence has since demonstrated that as well as having intrinsic catalytic activity, some introns code for proteins that ...

Ribozyme-mediated inhibition of survivin expression induces apoptosis. (a) TUNEL analysis of spontaneous apoptosis in DU145/CTR, DU145/RZ, PC-3/CTR and PC-3/RZ cells was carried out by flow cytometry.

Ribozyme treatment inhibited this increase in a dose-dependent manner (Figure 5d). Obviously, monitoring serum concentrations of PTN provides a direct read-out of the efficacy of the ribozyme ...