Previously, the leading RNA polymerase ribozyme, called R18, could only transcribe RNAs up to 14 bases long (as a frame of reference, R18 itself is about 196 bases long).

Penn State. "Ribozyme Package Effective Against Hepatitis B Virus." ScienceDaily. ScienceDaily, 23 March 2004. <www.sciencedaily.com / releases / 2004 / 03 / 040323074507.htm>.

So far, though, efforts to make a self-replicating ribozyme have come up short. Most RNA molecules with this sort of activity have been around 200 bases long and have tended to stall before ...

Scott’s structural observations of the hammerhead ribozyme, however, could not explain a growing number of biochemical experimental results. The hammerhead ribozyme has been the subject of intensive ...

Atomic-resolution Structure Of A Ribozyme Yields Insights Into RNA Catalysis And The Origins Of Life Date: July 22, 2006 Source: University of California - Santa Cruz Summary: Scientists have ...

The 24-3 ribozyme is thus the first ever to combine the two basic capabilities—RNA synthesis and RNA replication—necessary for a pre-protein, pre-DNA world of RNA life.

In fact, the percentage of each active ribozyme that was cleaved is quite similar to earlier efforts that tested ribozymes individually.” The team then looked at predicted structures of the sequences ...

Article #19-14282: "An RNA polymerase ribozyme that synthesizes its own ancestor," by Katrina F. Tjhung, Maxim N. Shokhirev, David P. Horning, and Gerald F. Joyce.

Second, the ribozyme cassette is engineered to cut itself into pieces, thereby freeing the HBV-targeted ribozymes from extraneous sequences that could interfere with their activity.

New ribozyme can make RNA molecules accessible for click chemistry in living cells RNA molecules are real all-rounders. They transfer the genetic information from the DNA in the cell.

More precisely: the ribozyme transfers a single methyl group to an exactly defined nitrogen atom of the target RNA. This makes it the first known methyl transferase ribozyme in the world. Accordingly, ...

Ribozyme-mediated inhibition of survivin expression induces apoptosis. (a) TUNEL analysis of spontaneous apoptosis in DU145/CTR, DU145/RZ, PC-3/CTR and PC-3/RZ cells was carried out by flow cytometry.