All living organisms encode the amino acid sequences of proteins as nucleotide sequences (genetic information) in their genomic DNA. The genetic information is transcribed and subsequently translated ...

Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized and translated into more protein, while directing others to be degraded and ...

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nature Communications, 2022; 13 (1) DOI: 10. ...

These are modifiable anticodons, and enable one tRNA to decode several synonymous codons through the wobble effect. The researchers analyzed the translation of I34 in the same protein. They determined ...

More information: Sophia Zborowsky et al, Adaptive loss of tRNA gene expression leads to phage resistance in a marine Synechococcus cyanobacterium, Nature Microbiology (2025).

To try and fix the mutation, he and his team mutated a human tRNA gene in a phage/ E. coli system to produce a sup-tRNA and injected it into a frog ovary cell carrying a β-thalassemia patient’s mRNA. ...

In a milestone achievement, a whole chromosome has been created from scratch by scientists for the first time ever. The tRNA Neochromosome is a man-made chromosome of the common baker's yeast ...