They observed that HIV-infected macrophages secreted the zymogen matrix metalloproteinase 2 (MMP-2), which is activated by exposure to MT1-MMP on neurons. SDF-1—a chemokine overexpressed by astrocytes ...

Seminal work on inflammation and vascular MMP biology is reviewed here and indicates a further need to test MMPIs in established and new animal models of inflammation, infection and ischaemia.

Moreover, he has aided the identification of a macrophage phenotype (under the control of GM-CSF) which is characterised by high MMP-12 and MMP-14 protein expression alongside low TIMP-3 levels.