For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

In the early stages of spastic paraplegia, the brain appears to play a major role by over-activating the immune system, as ...

Li Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presence of microglia in the peripheral nervous system (PNS) and identified ...

Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...

New study links norepinephrine to reduced brain inflammation in Alzheimer’s, offering a potential early treatment target.

Microglia are very dynamic and constantly extending and retracting processes to explore and monitor the brain. In this image from the new University of Rochester study, white shows the microglial cell ...

Microglia are special cells in the human brain. Like a diligent ranger overseeing a forest and dealing with infestations and wildfires, microglia scan the brain environment for germs and initiate ...

By engineering human immune cells called microglia, the researchers have created living cellular 'couriers' capable of responding to brain pathology and releasing therapeutic agents exactly where ...

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If inactivation of TNF-dependent inflammation in the brain is warranted by additional pre-clinical studies, selective targeting of TNFR1-mediated signaling while sparing TNFR2 activation may ...

LI Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presence of microglia in the peripheral nervous system (PNS) and identified ...