Objective: The physiology of counterregulatory responses during hypoglycemia ... oral combination therapy and antecedent hypoglycemia both blunt physiological defenses against subsequent ...

The mechanism that underlies the absence of a glucagon response to hypoglycemia in type 1 diabetes ... despite the absence of the usual physiological 'switch off' of insulin in these individuals.

and symptomatic responses to hypoglycemia the following day, specifically that it shifts the glycemic thresholds for these responses to lower plasma glucose concentrations. To do so we applied the ...