The study, published today in Cell Stem Cell, is the first to report that glial cells from MS patients have intrinsic hallmarks of disease, independent of immune system influences, which points to ...

But Shane Liddelow, Prakash's supervisor at NYU, says, in fact, neurons make up only about half the cells in a brain. SHANE LIDDELOW: The other half is all of these glial cells and these immune cells.

Glia, once thought to be mere glue that fills the space between neurons, were largely ignored in the brain for much of the 20th century. Clearly, neurons were the cells that made things happen ...

This suggests that glucose metabolism in glial cells acts downstream of tau accumulation — meaning that while the tau buildup triggers the problem, the glial response, shaped by metabolic ...

For example, glial cells are known to clear away abnormal build-up of protein, accompanied by an inflammatory response; neuroinflammation is a core pathology of AD.