The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the intricate arrangement of the glomerular endothelial cells, podocyte layers, and GBM in a single step.

In the paper titled, “ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease,” the authors reported ...

Gunter Wolf; Sheldon Chen; Fuad N. Ziyadeh Disclosures Diabetes. 2005;54 (6):1626-1634.

The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the intricate arrangement of the glomerular endothelial cells, podocyte layers, and GBM in a single step.

Initially, the researchers observed the specific expression of ADGRF5 within endothelial cells that line the glomerular capillary wall. In mice with genetic knockout of ADGRF5, the GFB was ...

The absence of Adhesion G-protein-coupled receptor F5 (ADGRF5) led to significant changes in gene expression in glomerular endothelial cells, disrupting the structure and function of the ...

Using unique conditionally immortalized human podocyte cell lines [9] and human glomerular sections, we have studied the effect of insulin on these cells and the mechanisms of glucose uptake ...