Neurons suffer dramatic impairments in autophagy both in the AD brain and in mouse models of amyloidosis (Nixon et al., 2005; Jun 2010 news; Jun 2022 news).While neurons need autophagy to clean up ...

Scientists have noted both beneficial and detrimental links between microglia and autophagy in the context of neurodegenerative disease. On one hand, there’s evidence that microglia carry out ...

In neurodegenerative diseases, microglia (mi-KROL-glee-uh) still kick into action, but in a way that actually impairs autophagy, that self-eating process that clears out toxins.

Here, we show that activated microglia mediate non-cell-autonomous inhibition of neuronal autophagy, a degradative pathway critical for the removal of toxic, aggregate-prone proteins accumulating ...

The brain and central nervous system have their own specialist immune cells, known as microglia, ... When activated, this switch – called CCR5 – impairs autophagy, ...

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes. Autophagy , 2023; 1 DOI: 10.1080/15548627.2023.2167689 Cite This Page : ...

Microglia are known to play an important role in Alzheimer's disease, but exactly what they do has remained a mystery. Scientists in the Bart De Strooper Lab at the VIB-KU Leuven Center for Brain ...

The microglia adopted a neuroprotective, disease-associated microglia (DAM)-like signature, Mirescu said. Vigil has begun Phase 1 dosing studies with VG-3927 in healthy volunteers, with data due later ...

Health Microglia: How the brain’s immune cells may be causing dementia. They fight invaders, clear debris and tend neural connections, but sometimes microglia go rogue.

Autophagy is a natural process in which your body breaks down and cleans out damaged cells. It is triggered by fasting and has been promoted for weight loss and longevity, although there is no ...