In almost all vertebrates, the downstream of the sox9 signaling axis is well conserved for testis differentiation. The upstream genes of this pathway vary from species to species during evolution.

Cambridge scientists have identified an ‘on/off’ switch in a type of cancer which typically occurs in the testes and ovaries called ‘malignant germ cell tumours’. The research was published today, 01 ...

When Sry, the testis determining gene, was identified in the early nineties, it was hoped that the other main players involved in the choice of making testes or ovaries would rapidly emerge.