When Sry, the testis determining gene, was identified in the early nineties, it was hoped that the other main players involved in the choice of making testes or ovaries would rapidly emerge.

In almost all vertebrates, the downstream of the sox9 signaling axis is well conserved for testis differentiation. The upstream genes of this pathway vary from species to species during evolution.

LONDON: Researchers from Cambridge have discovered a molecular “switch” that can turn off a highly virulent cancer of the testis and the ovary.The scientists found that all malignant germ cell ...

Gonadal sex cord-stromal tumors contain some of the most morphologically interesting neoplasms of the gonads and these lead to many important issues in differential diagnosis. The pathology of ...

Cambridge scientists have identified an ‘on/off’ switch in a type of cancer which typically occurs in the testes and ovaries called ‘malignant germ cell tumours’. The research was published today, 01 ...