Jaire Alexander, Edgerrin Cooper, Brock Purdy and Nick Bosa were all ruled out Friday; 49ers LT Trent Williams joins them on ...

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

The San Francisco 49ers received important Brock Purdy, Trent Williams and Nick Bosa injury updates on Wednesday.

The San Francisco 49ers will be missing two of their best players in their must-win matchup against the Green Bay Packers ...

The San Francisco 49ers will be without their starting quarterback and their best defensive player when they visit the Green ...

Bosa (hip/oblique) will not practice Wednesday, Nick Wagoner of ESPN.com reports. Bosa missed last Sunday's loss to the Packers after he was injured in the Week 11 loss to the Seahawks. Sam Okuayinonu ...

This just isn't the 49ers' week. They have now been dealt the worst-case scenario with Nick Bosa's status against the Packers ...

San Francisco 49ers tight end George Kittle confidently declared on Wednesday that he will suit up for this weekend's game ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 12 matchup vs. the Green Bay Packers ...

The San Francisco 49ers fell to 5-6 on the season in losing to the Green Bay Packers on Sunday. Top takeaways with Brock ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

San Francisco 49ers quarterback Brock Purdy (13) celebrates after scoring a touchdown with guard Aaron Banks, left, and guard ...