gut.bmj

Gut microbiota modulate T cell trafficking into human colorectal cancer

Objective Tumour-infiltrating lymphocytes (TILs) favour survival in human colorectal cancer (CRC). Chemotactic factors underlying their recruitment remain undefined. We investigated chemokines ...
gut.bmj

Antibiotic use and risk of colorectal cancer: a meta-analysis of 412 450 participants

2 West China School of Stomatology, Sichuan University, Chengdu, China Correspondence to Xiao-Ting Wu, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, West China ...
gut.bmj

Exposure to corticosteroids in pregnancy is associated with adverse perinatal outcomes among infants of mothers with inflammatory bowel disease: results from the PIANO registry

Objective Active inflammatory bowel disease (IBD) during pregnancy may require the use of corticosteroids. The aim of this study was to investigate the impact of in utero corticosteroid exposure on ...
Gut

CD177+ neutrophils: new drivers of liver regeneration

Liver resection remains the main curative option for many patients with primary and secondary liver malignancies, including ...
Gut

Revised version global guidelines on diverticular disease of the colon: the Fiesole Consensus report

Introduction Colonic diverticulosis is the most common structural abnormality of the colon in developed countries, with an increasing global prevalence. Approximately 20–25% of affected individuals ...
Gut

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
gut.bmj

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity

Objective Metabolic reprogramming of tumour cells that allows for adaptation to their local environment is a hallmark of cancer. Interestingly, obesity-driven and non-alcoholic steatohepatitis ...
gut.bmj

Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease

19 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore 24 Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai, ...
gut.bmj

Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia

Correspondence to Professor Mark Morrison, The University of Queensland Diamantina Institute and NHMRC Centre of Research Excellence Digestive Health, Faculty of Medicine, University of Queensland, ...
gut.bmj

Bacteria as the cause of ulcerative colitis

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
Gut

Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women

Background Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis. Objective The objective of this study was to ...
gut.bmj

IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these ...

Objective The interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes in these therapeutic trials ...