The hotspot at chr3q28 sits between the GMNC and osteocrin (OSTN) genes. They are involved in DNA replication and dendritic ...

“This gene-to-molecule research is crucial for discovery in Alzheimer’s disease. It offers fresh perspectives on how genetic risk factors, such as APOE, influence metabolism and perhaps disease ...

Strapped with an extra APP, people with Down’s syndrome are all but destined to develop Alzheimer’s dementia if they live ...

Brain age gap (BAG) is a useful metric because it predicts one’s age-adjusted vulnerability to a range of neurological disorders, such as AD, dementia, and stroke. Although brain age may indeed ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

Tapering. Spaghetti plots show that CSF NFL (right) rises more quickly in people with ADAD mutations (red) than in noncarriers (gray) and that this accelerates as disease progresses. In plasma (left), ...

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Application budgets are limited to $400,000 direct costs per year. The maximum project period is 3 years.

Application budgets are capped at $1 million in direct costs per year. The maximum project period is 5 years.

The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year. June 02, 2025 (Letter of Intent due May 1, 2025 ...