This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

Finding genetic variants associated with Alzheimer’s disease has been easier than figuring out exactly how they heighten risk. In the September 3 Nature, scientists led by Jubao Duan at the University ...

Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...

THY-Tau22 mice are a model for tau aggregation, a pathological hallmark of Alzheimer's disease as well as numerous tauopathies. With age these mice develop a variety of tau-related neuropathological ...

The highly selective border lining the brain’s vasculature is the Achilles’ heel of any large therapeutic molecule aiming for targets in the brain, anti-Aβ antibodies included. Not only do fewer than ...

Blood draws from across sub-Saharan Africa are underway. Samples are shipped from Nigeria to Miami. There, their genetics and biomarkers are being analyzed. According to the most recent Global Burden ...

It’s official: A new AI consortium to speed the pace of discoveries in AD research is off to the races. Its name? C-brAIn, emphasis evoking artificial intelligence intended. Alzforum first reported on ...

Blood tests for Alzheimer’s disease are now so accurate that a positive result, on its own, is reason enough for people who are suspected of having AD to start immunotherapy. So proffered Suzanne ...

The therapeutic antibody lecanemab has been in clinical use in the U.S. for two years, and doubts about whether it would be feasible for clinics to implement and manage this therapy have eased. Even ...

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

A selected list of scientific conferences relevant to researchers, clinicians and others interested in Alzheimer’s disease and related neurodegenerative disorders.

reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but ...