Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...
Comments For TDP-43 Aggregates, Breaking Up Is No Longer Hard to Do 13 May 2026 ...
The world did not end today as predicted, but unfortunately we have to report that development of another potential drug did. Allon Therapeutics Inc. announced 19 December that its drug candidate ...
Gareth Thomas, Ph.D. Lewis Katz School of Medicine at Temple University Contact Information Gareth Thomas, Ph.D. Philadelphia, United States ...
Lu AF87908 is a humanized mouse IgG1 monoclonal antibody to phosphorylated tau protein. It was generated by immunization of mice with a tau peptide spanning residues 386-408 and phosphorylated at ...
03 June 2026 DOWNLOAD TO YOUR CALENDAR London, U.K. View Conference Website ...
To clear plaque, lecanemab must activate microglia. Activated microglia turn on DAM genes such as osteopontin. Lecanemab covers Aβ42 protofibrils more densely than does aducanumab. Some scientists ...
Certain mutations in the GBA1 gene are the most common genetic risk factors for Parkinson’s disease; even so, most people with these variants never develop PD. Now, scientists led by Anthony Schapira ...
Interconnected networks of neurons—i.e., circuits—are the basis of brain function, and astrocytes support synapses within them. They also form networks of their own, passing messages and sharing ...
The U.S. Food and Drug Administration has delayed a decision on a subcutaneous starting dose for Eisai and Biogen’s amyloid antibody lecanemab. The agency had accepted the company’s supplemental ...
On April 28, Aligning Science Across Parkinson’s, aka ASAP, a philanthropic initiative backed by the Sergey Brin Family Foundation and The Michael J. Fox Foundation for Parkinson’s Research, together ...
Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...
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