03 June 2026 DOWNLOAD TO YOUR CALENDAR London, U.K. View Conference Website ...
Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...
The world did not end today as predicted, but unfortunately we have to report that development of another potential drug did. Allon Therapeutics Inc. announced 19 December that its drug candidate ...
Gareth Thomas, Ph.D. Lewis Katz School of Medicine at Temple University Contact Information Gareth Thomas, Ph.D. Philadelphia, United States ...
The U.S. Food and Drug Administration has delayed a decision on a subcutaneous starting dose for Eisai and Biogen’s amyloid antibody lecanemab. The agency had accepted the company’s supplemental ...
On April 28, Aligning Science Across Parkinson’s, aka ASAP, a philanthropic initiative backed by the Sergey Brin Family Foundation and The Michael J. Fox Foundation for Parkinson’s Research, together ...
To scientists peering through a microscope, lipofuscin presents as nuisance, interfering with immunohistochemical analysis. Could this poorly characterized, autofluorescent debris shine light on both ...
To clear plaque, lecanemab must activate microglia. Activated microglia turn on DAM genes such as osteopontin. Lecanemab covers Aβ42 protofibrils more densely than does aducanumab. Some scientists ...
Because blood is so easy to sample, scientists like to screen this biofluid when looking for disease associations. Alas, that is not the best approach for neurodegenerative disorders, according to ...
"The neurologist diagnosed conversion disorder (see Medline). I should not have believed that. We went to counseling sessions for a year but nothing happened." —Caregiver. Families with eFAD tell ...
Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...
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