Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416–1421 (2022)].The ...

In eukaryotes, genomic DNA is packaged into chromatin, which is the substrate for transcription, DNA replication, repair, and recombination. Within chromatin, nucleosomes contain two copies of each of ...

Despite these successes, polyhydride synthesis remains challenging. For instance, it took nearly a decade to experimentally realize CaH 6 (12, 13) after its theoretical prediction ().A major hurdle is ...

In the secretory pathway, the pH within organelles is gradually acidified, starting at 7.1 to 7.2 in the endoplasmic reticulum, decreasing to 6.0 to 6.7 in the Golgi apparatus/trans-Golgi network ...

FSP1 expression strongly correlates with cancer resistance to ferroptosis inducers and is associated with poor patient prognosis for some cancers (16, 17, 24).Genetic deletion of FSP1 sensitizes ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

During oogenesis, maternally derived protein/mRNA (e.g. Oskar, Vasa, Aubergine, Tudor) localize to the posterior pole for the formation of the germ plasm which possess the ability to induce primordial ...

Epidermal growth factor receptor (EGFR) overexpression is associated with multiple aggressive solid tumors. Despite recent advances in cancer therapy, and specifically in EGFR-targeted therapy, there ...