Cognitive decline during aging or in dementia with Lewy bodies (DLB) and motor dysfunction in Parkinson’s disease are associated with neurodegeneration of basal forebrain cholinergic neurons (BFCN).

Neurons that die early in Alzheimer’s help drive brain waste removal. Treating this process sooner could change outcomes.

By labeling neurons the team showed that the basal forebrain vGlut2+ excitatory neurons sent out projections to the lateral hypothalamus (LH), creating a direct, functional link between the BF and ...

The neural cells in a strategic brain region—the cholinergic basal forebrain—and their long cholinergic axons are selectively vulnerable to Alzheimer's disease pathology.

This paper also contains new preclinical work suggesting neflamapimod acts by restoring lysosomal function and preserving basal forebrain cholinergic neurons. These neurons are the main source of ...

Thus, at least for aversive stimuli, parvalbumin-expressing basal forebrain neurons might be the physical substrate of the ‘attention for learning’ concept. Advanced Search Home ...