Sphingosine 1- Phosphate Receptor 1 (S1PR1) has multiple protective effects on endothelial cells (ECs): it maintains barrier function thereby protecting against vascular leakage, it limits the number ...

UDP-galactose (UDP-Gal) can also be formed from galactose derived from dietary lactose Upon entering the cell, galactose is phosphorylated by the enzyme galactokinase, converting it into ...

Using CRISPR/Cas9, we generated HEK293T cell lines lacking key enzymes of the Leloir pathway: UDP-galactose 4′-epimerase (GALE), galactose-1-phosphate uridylyltransferase (GALT), or both. The knockout ...

Title of the original paper: Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.

Abstract The purpose of these studies is to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, dedifferentiation of Müller glia (MG), reprogramming into proliferating ...

A protocol for pretreatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions.

The sphingosine 1-phosphate (S1P)–S1P 1 receptor axis is involved in several steps of the inflammatory response, such as cell proliferation, vascular permeability, immune-cell trafficking, and ...

Proximod is a selective agonist of sphingosine-1-phosphate receptor-1 (S1PR1). It acts by redirecting lymphocytes from the circulation to secondary lymph nodes, and is under development as an ...

Aortic valve disease (AVD) is associated with high mortality and morbidity. To date, there is no pharmacological therapy available to prevent AVD progression. Because valve calcification is the ...