New research by scientists at the University of Toronto and the Structural Genomics Consortium has deepened our understanding ...

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read ...

Yet, despite more than 20 years of study, the sweet receptor’s precise architecture remained elusive, even as scientists ...

This is an important study utilizing innovative CRISPR based approaches demonstrating the role of the KLF family of transcription factors in the post natal maturation of cortical projection neurons.

Oregon Health & Science University, in collaboration with Oregon State University, has discovered the structural organization ...

This information, alongside a visual assessment of the residue locations on the predicted structure of Con1, led to the final plan for variant creation. The identity of the random protease variants ...

Chagas disease (CD) is a neglected tropical disease for which novel and improved treatments are needed. The cysteine protease Cruzipain is one of the main targets for the development of novel drugs ...

File Tree Generator helps developers maintain up-to-date documentation of their project structure by automatically generating file tree diagrams in text or markdown format. The plugin integrates ...

In this study, changes in the protein structure of the main protease due to mutations in SARS-CoV-2 North American isolates and the effects of these changes on boceprevir affinity, an important ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells change their metabolic profiles in ...

To rationalize the de-acetoacetylation activity of HDAC3, small-molecule substrate mimics containing acyllysine (acetyllysine mimic or acetoacetyllysine mimic) were docked into the crystal structure ...