We knew that a major contributor is the muscle stem cells that are needed to repair muscle damage. They become dysfunctional with age.

Stem cells that live in the muscle impart its ability to regenerate. After an injury, muscle stem cells activate and must expand in number to repair and make new muscle (marked by dystrophin in ...

The U.S. health secretary said people should have access to experimental therapies including unregulated uses of stem cells. But some methods have resulted in blindness, tumors and other injuries.

Dyno Therapeutics launches three breakthrough capsid delivery vectors for next-generation eye, muscle and CNS gene therapies at ASGCT 2025 ...

The researchers’ work in zebrafish revealed how muscle cells have an intrinsic timekeeping mechanism that regulates protein turnover, modulating muscle growth and function.

Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial ...

This fundamental research conducted a molecular comparison between smooth muscle cells and adjacent fibroblast cells within lung blood vessels affected by pulmonary arterial hypertension. The study ...

Figure 1. Diagram of traction force microscopy experiments. Vascular smooth muscle cells (VSMCs) are seeded on elastic substrates (polyacrylamide (PA) gel) that contain fluorescent particles on the ...

The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs). Aging and disease are associated with dramatic changes in ECM composition ...

Further, we demonstrated that overexpressing miR-3529 induces human aortic smooth muscle cells (HASMCs) homeostasis disruption. Gain- and loss-of-function experiments revealed that this miRNA ...

In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and ...