Proteins are life's molecular workhorses, doing everything from turning sunlight into food to fighting viruses. They are ...

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Human galectin-3 (hGal-3) is a target protein implicated in various diseases, including fibrosis, and several inhibitors have been identified. In this study, we investigated the quantitative structure ...

A timeline of the praises and insults that President Trump and Elon Musk have lobbed at each other shows how their volatile clash was years in the making.

Ultrasonic extraction has the advantage of higher efficiency in the extraction of F. velutipes polysaccharides (FVP), but the structure and activities with application value of FVP extracted by ...

We leverage our pathogenic fungal CaN-FK506-FKBP12 complex X-ray structures and biophysical data to support structure-based ligand design as well as structure–activity relationship analyses of ...

We systemically examine the structure-activity relationship of GL, GA and their isomers. Based on the various pharmacological activities of GL, GA and their isomers, we propose further development of ...

In this study, we carried out structure-activity relationships (SARs) for bupropion and ibogaine with the goal of identifying the chemical features required for pharmacological chaperone activity. Our ...