A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation. The case ...

A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation.

After decades of limited progress—owing to the difficulty of treating the disease and resultant market risk—glioblastoma ...

Both radiation and temozolomide, a generic chemotherapy treatment in pill form, have meaningful single-modality anti-tumor activity against slow-growing, low-grade gliomas. The randomized phase 3 ...

While temozolomide improves survival in some patients, conflicting data suggest it may not be effective in all cases. Based on this current unmet need in the patient population, researchers set out to ...

Temozolomide plus vincristine and irinotecan is now standard treatment in Europe for relapsed rhabdomyosarcoma, Defachelles said. – by Mark Leiser Reference: Defachelles AS, et al. Abstract 10000.

The addition of temozolomide to radiation therapy prolonged OS for patients with both co-deleted and non-co-deleted grade 2 gliomas, according to study results.These are the first data from a ...

Methods: Eighty newly diagnosed GBM patients were enrolled after their craniotomy between December 2009 and December 2010. Patients received standard radiation therapy and temozolomide at 75 mg/m 2 /d ...

Abstract Purpose To evaluate tumor response, pharmacodynamic effects, and safety of a combination of lomeguatrib (LM), an O6 -methylguanine DNA-methyltransferase (MGMT) inactivator, and temozolomide ...

Methotrexate (MTX)-based chemotherapy extends survival in patients with primary brain lymphomas, but it is not clear whether multiagent chemotherapy is superior to MTX alone. Treatment options for ...

Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O6 position of guanine in DNA. Resistance to ...

Temozolomide (Temodar) generic is an anticancer agent, used for brain cancers i.e. anaplastic astrocytoma and glioblastoma multiforme. It is also used for treating melanoma.