When the skin is injured, a stem cell’s survival instincts kick in. New research reveals that a simple amino acid, serine, ...

Tridecanoic acid (C13) is a rare, odd-chain saturated fatty acid produced mainly by gut and rumen microbes, entering metabolic pathways via β-oxidation to support gluconeogenesis and the TCA cycle.

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...

Results RV‐PA coupling was negatively associated with tricarboxylic acid (TCA) cycle intermediate levels. Specifically, plasma α‐ketoglutarate and fumarate were significantly associated with all ...

Explorative analyses of 48 h urine, both by 1H NMR and LC–MS metabolomic platforms, demonstrated higher urinary excretion of tricarboxylic acid (TCA) cycle intermediates citric acid and succinic acid ...

During homeostasis and regeneration, satellite cells, the resident stem cells of skeletal muscle, have distinct metabolic requirements for fate transitions between quiescence, proliferation and ...

Butyrate and other SCFAs provide abundant energy to the intestinal epithelial cells by β-oxidation in the mitochondrial tricarboxylic acid cycle (TCA cycle) [5, 34] (Fig. 3 A). Second, butyrate also ...

The complete tricarboxylic acid (TCA) cycle, comprising a series of 8 oxidative reactions, occurs in most eukaryotes in the mitochondria and in many prokaryotes. The net outcome of these 8 chemical ...

This study presents an assessment of the effect of lactate dehydrogenase (LDH) inhibition on the activity of glycolysis and tricarboxylic acid cycle. The data were collected and analyzed using solid ...

Bifidobacterium breve supplementation in pregnant mice alters fetal brain metabolism, highlighting its role in enhancing ...