eLife1d
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest
In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...
eLife1d
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
This paper aims to understand why prostate cancer with CDK12 loss does not respond to HRd-based therapeutics, such as PARP inhibitors. The work is felt to be fundamental given a thorough computational ...
eLife1d
Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features
Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features that contribute to retinoblastomagenesis. The ...
eLife2d
Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...
eLife2d
Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal
The latent HIV reservoir is a major barrier to HIV cure. Combining latency reversal agents (LRAs) with differing mechanisms of action such as AZD5582, a non-canonical NF-kB activator, and I-BET151, a ...
eLife2d
Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages
The authors use a multidisciplinary approach to provide a useful link between Beta-alanine and S. Typhimurium (STM) infection and virulence. The work shows how Beta-alanine synthesis mediates zinc ...
eLife2d
Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric feedback
Sainsbury Wellcome Centre for Neuronal Circuits and Behavior, University College London, London, United Kingdom ...
eLife2d
Enhanced bacterial chemotaxis in confined microchannels: Optimal performance in lane widths matching circular swimming radius
This valuable study examines the effects of side-wall confinement on the chemotaxis of swimming bacteria in a shallow microfluidic channel. The authors present solid experimental evidence, combined ...
eLife2d
CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells
This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...
eLife3d
Estimating bone marrow adiposity from head MRI and identifying its genetic architecture
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. The authors of this ...
eLife3d
The eLife Model: An update on progress following changes in Web of Science indexing status
Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing ...