The patient had high levels of alkaline phosphatase and immunoglobulin G4 (IgG4), high IgG4/IgG ratio, was positive for antimitochondrial antibodies and had lymphoplasmacytic infiltration and ...

The median alkaline phosphatase levels went down from 138 U/L to 85 U/L after 1 year of treatment with pemafibrate plus ursodeoxycholic acid. Pemafibrate plus ursodeoxycholic acid (UDCA) results in ...

KIT D816 variants correlate with spindled mast cells, while milder mutations associate with round-cell morphology. Distinct gain-of-function mutations in the KIT gene underlie variable morphologic ...

More than 90% of cases of pediatric mastocytosis are cutaneous rather than systemic mastocytosis. A child with itchy maculopapular lesions across her body was subsequently diagnosed with cutaneous ...

Pulmonary rehabilitation is an underutilized tool in the management of PAH. Referrals to pulmonary rehabilitation among patients with pulmonary arterial hypertension (PAH) are relatively low despite ...

The disease burden in PAH is both personal and macroeconomic; both have to be approached with strategy, tact, and empathy. In scientific literature, “disease burden” usually refers to one of two ...

Male sex and older age were both associated with increased tumor risk, and the risk of death among the patients quadrupled after the diagnosis of a tumor. Malignancy is a significant contributor to ...

Magnetic resonance imaging revealed a longitudinally extensive lesion in the lower medulla and upper cervical cord with an obvious trident-shape. A team of researchers from China presented the case of ...

HIF-1α inhibition mitigated hypoxia-induced pulmonary vascular pathology in lupus model in mice. Inhibition of hypoxia-inducible factor-1α (HIF-1α) significantly reduced pulmonary arterial remodeling ...

Patients in the low TyG index group had higher survival rates than those in the high TyG group, and this result was maintained across patient subgroups. The triglyceride-glucose (TyG) index is an ...

The model showed an external test accuracy of 97% in classifying samples as HCC, CCA, or normal liver, thereby reducing the risk of misdiagnoses. A new deep learning framework combined with image ...

I like to play games. The Words With Friends app and online puzzles, like Connections on the New York Times app, keep me thinking. Online games can be important to someone with multiple sclerosis (MS) ...