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Are vaccines quietly reprogramming population immunity via regulatory T-cells? (update #208)
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TheTalas on Instagram: "The 2025 Nobel Prize in Physiology or Medicine was awarded not for a new drug or a single experiment, but for a fundamental explanation of why the immune system usually does not destroy the body it is meant to protect. For decades, immunology focused on how immunity attacks. What was missing was a clear answer to the opposite question: how immunity learns restraint. The laureates — Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi — solved this by uncovering the mechan
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Regulatory T cells (Tregs) (CD4 CD25 FoxP3 ) are primarily targeted in cancer treatment to reverse their immunosuppressive effects within the tumor microenvironment, which allows tumors to escape immune surveillance. Strategies include depleting intratumoral Tregs, inhibiting their function, or modulating their metabolism to boost anti-tumor immune responses. Key aspects of Treg modulation in cancer treatment: Mechanism of Action: Tumors often show high infiltration of Tregs, which suppress effe
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Facebookrisesknowledge
Асия Уракова on Instagram: "Долгие годы считалось, что когда иммунитет атакует своё, система просто сошла с ума, будто сигнал тревоги застрял в положении «всегда», но оказалось — проблема не в атаке, а в том, что кто-то однажды вытащил предохранитель, который должен был вовремя останавливать огонь. В лабораториях это описывали почти шёпотом: антигены собственного организма не подавляются, потому что нет клетки, которая говорит остальным «хватит», FOXP3 оказался тем самым регулятором, без которог
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Han pasado ya 30 años desde su descubrimiento y ayer recibieron el Premio Nobel. En 1995 Shimon Sakaguchi descubrió las células T reguladoras por primera vez, y en 2001 Mary Brunkow y Fred Ramsdell identificaron el gen FOXP3, clave para su desarrollo. #NobelMedicina2025 #Inmunología #nobel2025 #medicine #stem
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